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Interestingly, similar to epilepsy, both neuroinflammation and oxidative stress are associated with progressive impairment of the BBB/BSCS in ALS
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Effects of GLP-1R activation in the heart The observation that GLP-1 decreases contractility in primary culture of adult rat cardiomyocytes, despite increasing cAMP levels, [38] has also been reported in isolated rat hearts [45]